2022年2月16日 星期三

[小兒腫瘤] neuroblastoma versus Wilms tumor

Neuroblastoma 跟 Wilms tumor 都是經常出現在腹腔的腫瘤, 也經常被問到, 以下就來列表整理

 

Neuroblastoma

Wilms tumor

Age

< 2y/o

Peak 3-4 y/o

Clinical presentation

Painful abdomen mass

Painless abdomen mass

Origin

Retroperitoneal neural crest

Kidney

Calcification

Classic eggshell calcification on x-ray (85%)

No tumor calcification, but may have calcification for hemorrhage

Kidney involvement

Displace kidney, but does not distort renal architecture

Disrupt renal architecture

Vessel involvement

Encase

Invasive

Metastatic site

LN, bone marrow, liver, skin
(rarely to lung or brain)

Lung, liver, bone

Cross midline

Frequently

Rarely

Staging work-up

CT/MRI abdomen, bone scan, urine VMA and HVA, MIBG,
bone marrow biopsy

CT/MRI abdomen, CT chest

Prognostic factor

Stage, histology, age, MYCN status

Stage, histology, age, 1q gain, LOH 1p/16q

Special stage

4S

V(bilateral)

References:

1. Essentials of clinical radiation oncology 2th edition
2. ASTRO's annual refresher course


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