[小兒腫瘤] neuroblastoma versus Wilms tumor

Neuroblastoma 跟 Wilms tumor 都是經常出現在腹腔的腫瘤, 也經常被問到, 以下就來列表整理

	Neuroblastoma	Wilms tumor
Age	< 2y/o	Peak 3-4 y/o
Clinical presentation	Painful abdomen mass	Painless abdomen mass
Origin	Retroperitoneal neural crest	Kidney
Calcification	Classic eggshell calcification on x-ray (85%)	No tumor calcification, but may have calcification for hemorrhage
Kidney involvement	Displace kidney, but does not distort renal architecture	Disrupt renal architecture
Vessel involvement	Encase	Invasive
Metastatic site	LN, bone marrow, liver, skin (rarely to lung or brain)	Lung, liver, bone
Cross midline	Frequently	Rarely
Staging work-up	CT/MRI abdomen, bone scan, urine VMA and HVA, MIBG, bone marrow biopsy	CT/MRI abdomen, CT chest
Prognostic factor	Stage, histology, age, MYCN status	Stage, histology, age, 1q gain, LOH 1p/16q
Special stage	4S	V(bilateral)

References:

1. Essentials of clinical radiation oncology 2th edition

2. ASTRO's annual refresher course