2019年5月20日 星期一

[腦瘤] WHO 2016分類

腦瘤(brain tumor)的分類標準由WHO在2016年更新, 之前的分類方法只看組織學型態來做分類, 新版分期多考慮了基因和影像特徵

組織學特徵主要是看這四個: nuclear atypia, cellularity and mitosis, endothelial proliferation, necrosis

WHO grade   I: no factors present
WHO grade  II: atypia
WHO grade III: atypia, mitoses
WHO grade IV: endothelial proliferation or necrosis

先來看glioma 分類(grade I, II 被稱為low-grade glioma; grade III,IV 被稱為 high-grade glioma):

WHO grade   I: pilocytic astrocytoma, subependymal giant cell tumor
WHO grade  II: diffuse astrocytoma, oligodendroglioma with IDH mutant/1p19q co-deleted, oligostrocytoma
WHO grade III: anaplastic astrocytoma(AA), anaplastic olidendroglioma(AO), anaplastic oligoastrocytoma(AOA)
WHO grade IV: GBM

reference:

1. handbook of evidence-based radiation oncology
2. radiation oncology a question based review

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